This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for WWOX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WWOX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WWOX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:77,236,023–77,236,607 | 863.2 kb | Distal (>10kb) Multiome HiCAR | 599 | |
| chr16:77,966,839–77,967,995 | 131.9 kb | Distal (>10kb) Multiome | 200 | |
| chr16:77,992,181–77,992,902 | 106.8 kb | Distal (>10kb) Multiome | 103 | |
| chr16:78,002,937–78,003,483 | 96.3 kb | Distal (>10kb) Multiome | 327 | |
| chr16:78,045,597–78,046,283 | 53.3 kb | Distal (>10kb) Multiome | 839 | |
| chr16:78,071,935–78,072,676 | 27.0 kb | Distal (>10kb) Multiome | 218 | |
| chr16:78,099,188–78,100,419 | 148 bp | At TSS Multiome | 1035 | |
| chr16:78,243,715–78,244,828 | 145.2 kb | Distal (>10kb) Multiome | 121 | |
| chr16:78,307,398–78,308,480 | 208.2 kb | Distal (>10kb) Multiome | 66 | |
| chr16:78,308,568–78,309,414 | 209.5 kb | Distal (>10kb) Multiome | 17 |
Genomic view of the WWOX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.