This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for WSB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WSB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WSB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:117,968,587–117,969,787 | 93.2 kb | Distal (>10kb) Multiome | 508 | |
| chr12:118,016,461–118,017,217 | 45.7 kb | Distal (>10kb) Multiome | 782 | |
| chr12:118,059,537–118,060,430 | 2.6 kb | Proximal (<10kb) Multiome | 222 | |
| chr12:118,060,617–118,061,718 | 1.1 kb | Proximal (<10kb) Multiome | 532 | |
| chr12:118,061,990–118,062,532 | 876 bp | At TSS | 378 | |
| chr12:118,103,306–118,104,597 | 41.5 kb | Distal (>10kb) Multiome | 730 | |
| chr12:118,119,571–118,120,301 | 57.3 kb | Distal (>10kb) Multiome | 62 | |
| chr12:118,120,669–118,121,341 | 58.5 kb | Distal (>10kb) Multiome | 428 | |
| chr12:118,135,872–118,136,757 | 73.7 kb | Distal (>10kb) Multiome | 914 |
Genomic view of the WSB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.