This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WSB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WSB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WSB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:27,276,603–27,277,135 | 17.3 kb | Distal (>10kb) Multiome | 146 | |
| chr17:27,293,463–27,295,350 | 43 bp | At TSS Multiome | 1050 | |
| chr17:27,332,329–27,333,408 | 38.9 kb | Distal (>10kb) Multiome | 951 | |
| chr17:27,339,666–27,340,740 | 46.2 kb | Distal (>10kb) Multiome | 417 | |
| chr17:27,345,040–27,345,796 | 51.4 kb | Distal (>10kb) Multiome | 236 | |
| chr17:27,348,891–27,350,020 | 55.2 kb | Distal (>10kb) Multiome | 369 | |
| chr17:27,353,475–27,354,485 | 59.8 kb | Distal (>10kb) Multiome | 870 | |
| chr17:27,455,680–27,457,139 | 162.2 kb | Distal (>10kb) Multiome | 616 |
Genomic view of the WSB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.