WRAP53

WD repeat containing antisense to TP53 | FLJ10385, TCAB1, WDR79

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

Member of: DE-1 DE-1.45

Biological processes 42 terms

Cajal body (GO:0015030)Cajal body (GO:0015030)Cajal body (GO:0015030)Cajal body (GO:0015030)Cajal body organization (GO:0030576)Cajal body organization (GO:0030576)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA folding (GO:0034337)RNA folding chaperone (GO:0140691)RNA folding chaperone (GO:0140691)chromosome (GO:0005694)chromosome, telomeric region (GO:0000781)cytosol (GO:0005829)histone binding (GO:0042393)identical protein binding (GO:0042802)nuclear body (GO:0016604)nucleoplasm (GO:0005654)positive regulation of DNA repair (GO:0045739)positive regulation of double-strand break repair (GO:2000781)positive regulation of double-strand break repair via homologous recombination (GO:1905168)positive regulation of double-strand break repair via nonhomologous end joining (GO:2001034)positive regulation of establishment of protein localization to telomere (GO:1904851)positive regulation of telomere maintenance via telomerase (GO:0032212)protein binding (GO:0005515)protein carrier activity (GO:0140597)protein localization to Cajal body (GO:1904867)protein-containing complex binding (GO:0044877)protein-folding chaperone binding (GO:0051087)scaRNA localization to Cajal body (GO:0090666)scaRNA localization to Cajal body (GO:0090666)site of double-strand break (GO:0035861)telomerase RNA binding (GO:0070034)telomerase RNA binding (GO:0070034)telomerase RNA localization to Cajal body (GO:0090671)telomerase holoenzyme complex (GO:0005697)telomere formation via telomerase (GO:0032203)telomere maintenance via telomerase (GO:0007004)telomere maintenance via telomerase (GO:0007004)telomere maintenance via telomerase (GO:0007004)ubiquitin protein ligase binding (GO:0031625)

Expression (TPM)

TFs regulating WRAP53 0 TFs

Transcription factors with Perturb-seq knockdown data for WRAP53. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WRAP53 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to WRAP53

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WRAP53, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:7,393,924–7,395,223	293.8 kb	Distal (>10kb) Multiome	744
chr17:7,403,290–7,405,695	284.1 kb	Distal (>10kb) Multiome	838
chr17:7,435,167–7,437,681	251.4 kb	Distal (>10kb) Multiome	828
chr17:7,437,892–7,438,555	250.2 kb	Distal (>10kb) Multiome	224
chr17:7,440,048–7,441,211	247.8 kb	Distal (>10kb) Multiome	487
chr17:7,444,968–7,446,142	242.9 kb	Distal (>10kb) Multiome	632
chr17:7,455,450–7,456,019	232.8 kb	Distal (>10kb) Multiome	414
chr17:7,478,839–7,480,126	208.9 kb	Distal (>10kb) Multiome	574
chr17:7,483,139–7,485,576	204.0 kb	Distal (>10kb) Multiome	1156
chr17:7,548,693–7,549,285	139.5 kb	Distal (>10kb) Multiome	387
chr17:7,560,249–7,562,536	126.5 kb	Distal (>10kb) Multiome	759
chr17:7,572,039–7,574,418	114.6 kb	Distal (>10kb) Multiome	1071
chr17:7,579,018–7,579,876	109.0 kb	Distal (>10kb) Multiome	844
chr17:7,583,063–7,584,547	104.7 kb	Distal (>10kb) Multiome	921
chr17:7,588,871–7,590,534	98.3 kb	Distal (>10kb) Multiome	319
chr17:7,614,065–7,615,780	73.4 kb	Distal (>10kb) Multiome	708
chr17:7,627,090–7,628,247	60.6 kb	Distal (>10kb) Multiome	712
chr17:7,650,010–7,652,127	37.7 kb	Distal (>10kb) Multiome	467
chr17:7,685,876–7,686,907	2.2 kb	Proximal (<10kb) Multiome	765
chr17:7,687,214–7,687,777	968 bp	At TSS Multiome	710
chr17:7,687,867–7,688,863	153 bp	At TSS Multiome	700
chr17:7,703,383–7,703,975	15.2 kb	Distal (>10kb) Multiome	141
chr17:7,704,799–7,705,590	16.7 kb	Distal (>10kb) Multiome	325
chr17:7,716,832–7,717,983	28.9 kb	Distal (>10kb) Multiome	759
chr17:7,833,417–7,837,960	147.1 kb	Distal (>10kb) Multiome	1160
chr17:7,841,438–7,843,228	153.7 kb	Distal (>10kb) Multiome	861
chr17:7,843,355–7,844,130	155.1 kb	Distal (>10kb) Multiome	614
chr17:7,844,349–7,845,186	156.4 kb	Distal (>10kb) Multiome	617
chr17:7,851,538–7,852,239	163.4 kb	Distal (>10kb) Multiome	531
chr17:7,856,600–7,858,747	169.1 kb	Distal (>10kb) Multiome	942
chr17:7,885,205–7,885,734	196.9 kb	Distal (>10kb) Multiome	371
chr17:7,887,616–7,888,198	199.4 kb	Distal (>10kb) Multiome	581
chr17:7,915,430–7,916,499	227.5 kb	Distal (>10kb) Multiome	869
chr17:7,922,863–7,923,421	234.5 kb	Distal (>10kb) Multiome	205
chr17:7,929,559–7,930,172	241.4 kb	Distal (>10kb) Multiome	106
chr17:7,931,533–7,932,876	243.6 kb	Distal (>10kb) Multiome	767
chr17:7,971,685–7,972,375	283.5 kb	Distal (>10kb) Multiome	45

Genome Browser

Genomic view of the WRAP53 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.