The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for WNK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WNK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WNK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:93,058,154–93,059,241 | 125.5 kb | Distal (>10kb) Multiome | 417 | |
| chr9:93,094,880–93,097,281 | 88.2 kb | Distal (>10kb) Multiome | 813 | |
| chr9:93,133,298–93,134,791 | 49.9 kb | Distal (>10kb) Multiome | 796 | |
| chr9:93,159,802–93,160,270 | 24.0 kb | Distal (>10kb) Multiome | 500 | |
| chr9:93,183,782–93,185,608 | 6 bp | At TSS Multiome | 401 | |
| chr9:93,193,426–93,193,661 | 9.3 kb | Proximal (<10kb) | 43 | |
| chr9:93,346,091–93,346,711 | 162.2 kb | Distal (>10kb) Multiome | 137 | |
| chr9:93,364,969–93,366,461 | 181.6 kb | Distal (>10kb) Multiome | 123 | |
| chr9:93,450,848–93,452,597 | 267.5 kb | Distal (>10kb) Multiome | 770 | |
| chr9:93,453,260–93,453,968 | 269.5 kb | Distal (>10kb) Multiome | 535 |
Genomic view of the WNK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.