This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WIPF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WIPF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WIPF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:39,926,716–39,928,343 | 291.7 kb | Distal (>10kb) Multiome | 942 | |
| chr17:39,952,356–39,953,923 | 266.2 kb | Distal (>10kb) Multiome | 598 | |
| chr17:39,979,964–39,981,234 | 238.7 kb | Distal (>10kb) Multiome | 1148 | |
| chr17:40,054,311–40,054,810 | 164.8 kb | Distal (>10kb) Multiome | 694 | |
| chr17:40,062,700–40,063,624 | 156.4 kb | Distal (>10kb) Multiome | 609 | |
| chr17:40,075,390–40,075,997 | 143.7 kb | Distal (>10kb) Multiome | 556 | |
| chr17:40,098,950–40,099,858 | 120.1 kb | Distal (>10kb) Multiome | 997 | |
| chr17:40,100,155–40,101,301 | 118.6 kb | Distal (>10kb) Multiome | 954 | |
| chr17:40,111,702–40,112,164 | 107.5 kb | Distal (>10kb) Multiome | 678 | |
| chr17:40,113,185–40,113,691 | 106.0 kb | Distal (>10kb) Multiome | 864 | |
| chr17:40,121,452–40,123,602 | 97.5 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,139,909–40,141,108 | 79.0 kb | Distal (>10kb) Multiome | 1121 | |
| chr17:40,177,152–40,178,398 | 41.9 kb | Distal (>10kb) Multiome | 329 | |
| chr17:40,191,326–40,192,022 | 27.6 kb | Distal (>10kb) Multiome | 588 | |
| chr17:40,218,712–40,219,963 | 37 bp | At TSS Multiome | 901 | |
| chr17:40,287,308–40,288,608 | 68.4 kb | Distal (>10kb) Multiome | 870 | |
| chr17:40,306,565–40,307,697 | 87.7 kb | Distal (>10kb) Multiome | 366 | |
| chr17:40,316,576–40,317,119 | 97.4 kb | Distal (>10kb) Multiome | 557 | |
| chr17:40,317,794–40,318,727 | 98.8 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,341,205–40,342,644 | 122.6 kb | Distal (>10kb) Multiome | 835 | |
| chr17:40,344,939–40,346,042 | 126.0 kb | Distal (>10kb) Multiome | 730 | |
| chr17:40,362,469–40,363,831 | 143.5 kb | Distal (>10kb) Multiome | 846 | |
| chr17:40,417,289–40,418,494 | 198.7 kb | Distal (>10kb) Multiome | 793 | |
| chr17:40,422,953–40,423,555 | 203.8 kb | Distal (>10kb) Multiome | 242 | |
| chr17:40,442,866–40,444,146 | 224.1 kb | Distal (>10kb) Multiome | 774 | |
| chr17:40,483,550–40,484,556 | 264.6 kb | Distal (>10kb) Multiome | 84 | |
| chr17:40,499,140–40,499,767 | 280.2 kb | Distal (>10kb) Multiome | 358 |
Genomic view of the WIPF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.