This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WIPF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WIPF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WIPF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:174,395,360–174,396,472 | 287.1 kb | Distal (>10kb) Multiome | 847 | |
| chr2:174,486,155–174,487,807 | 195.7 kb | Distal (>10kb) Multiome | 793 | |
| chr2:174,681,628–174,683,737 | 32 bp | At TSS Multiome | 464 | |
| chr2:174,684,945–174,685,122 | 2.0 kb | Proximal (<10kb) | 14 | |
| chr2:174,729,757–174,730,844 | 47.4 kb | Distal (>10kb) Multiome | 185 | |
| chr2:174,771,448–174,772,436 | 89.0 kb | Distal (>10kb) Multiome | 457 | |
| chr2:174,788,536–174,789,234 | 105.8 kb | Distal (>10kb) Multiome | 107 | |
| chr2:174,925,097–174,925,704 | 242.6 kb | Distal (>10kb) Multiome | 80 | |
| chr2:176,091,485–176,093,664 | 1409.8 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr2:176,096,693–176,099,096 | 1414.8 kb | Distal (>10kb) Multiome HiCAR | 661 |
Genomic view of the WIPF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.