Transcription factors with Perturb-seq knockdown data for WDR86. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR86 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR86, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:151,110,933–151,111,501 | 298.8 kb | Distal (>10kb) Multiome | 365 | |
| chr7:151,114,416–151,115,951 | 294.6 kb | Distal (>10kb) Multiome | 279 | |
| chr7:151,123,775–151,124,402 | 286.0 kb | Distal (>10kb) Multiome | 399 | |
| chr7:151,125,352–151,126,446 | 284.1 kb | Distal (>10kb) Multiome | 283 | |
| chr7:151,166,900–151,168,657 | 241.7 kb | Distal (>10kb) Multiome | 533 | |
| chr7:151,172,589–151,173,067 | 237.3 kb | Distal (>10kb) Multiome | 592 | |
| chr7:151,226,743–151,227,948 | 182.7 kb | Distal (>10kb) Multiome | 820 | |
| chr7:151,232,039–151,233,087 | 177.6 kb | Distal (>10kb) Multiome | 692 | |
| chr7:151,244,849–151,245,940 | 164.4 kb | Distal (>10kb) Multiome | 325 | |
| chr7:151,247,809–151,249,951 | 161.2 kb | Distal (>10kb) Multiome | 522 | |
| chr7:151,251,506–151,252,414 | 158.1 kb | Distal (>10kb) Multiome | 448 | |
| chr7:151,259,810–151,260,360 | 150.0 kb | Distal (>10kb) Multiome | 135 | |
| chr7:151,275,718–151,276,602 | 133.8 kb | Distal (>10kb) Multiome | 99 | |
| chr7:151,276,919–151,277,487 | 132.8 kb | Distal (>10kb) Multiome | 367 | |
| chr7:151,303,363–151,304,005 | 106.4 kb | Distal (>10kb) Multiome | 458 | |
| chr7:151,306,906–151,307,424 | 103.0 kb | Distal (>10kb) Multiome | 60 | |
| chr7:151,341,187–151,342,118 | 68.3 kb | Distal (>10kb) Multiome | 757 | |
| chr7:151,408,879–151,410,989 | 54 bp | At TSS Multiome | 407 | |
| chr7:151,439,682–151,441,031 | 30.1 kb | Distal (>10kb) Multiome | 189 | |
| chr7:151,448,171–151,448,932 | 38.6 kb | Distal (>10kb) Multiome | 403 | |
| chr7:151,519,052–151,521,056 | 110.1 kb | Distal (>10kb) Multiome | 899 | |
| chr7:151,631,518–151,633,118 | 222.3 kb | Distal (>10kb) Multiome | 611 | |
| chr7:151,705,224–151,705,878 | 295.6 kb | Distal (>10kb) Multiome | 192 |
Genomic view of the WDR86 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.