WDR83OS

WD repeat domain 83 opposite strand | PAT10, PTD008, C19orf56

Enables protein folding chaperone. Involved in multi-pass transmembrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Part of multi-pass translocon complex and protein folding chaperone complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1

Biological processes 13 terms

endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)multi-pass translocon complex (GO:0160064)multi-pass transmembrane protein insertion into ER membrane (GO:0160063)protein binding (GO:0005515)protein folding (GO:0006457)protein folding chaperone (GO:0044183)protein folding chaperone (GO:0044183)protein folding chaperone (GO:0044183)protein insertion into ER membrane (GO:0045048)protein insertion into ER membrane (GO:0045048)protein insertion into ER membrane (GO:0045048)

Expression (TPM)

TFs regulating WDR83OS 0 TFs

Transcription factors with Perturb-seq knockdown data for WDR83OS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR83OS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to WDR83OS

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR83OS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:11,243,345–11,243,968	1425.9 kb	Distal (>10kb) Multiome HiCAR	448
chr19:11,374,474–11,375,717	1294.5 kb	Distal (>10kb) Multiome HiCAR	866
chr19:11,481,847–11,483,040	1186.7 kb	Distal (>10kb) Multiome HiCAR	938
chr19:12,400,090–12,401,657	268.2 kb	Distal (>10kb) Multiome	671
chr19:12,440,217–12,441,483	228.3 kb	Distal (>10kb) Multiome	565
chr19:12,484,131–12,485,387	184.6 kb	Distal (>10kb) Multiome	664
chr19:12,495,009–12,495,882	174.0 kb	Distal (>10kb) Multiome	824
chr19:12,550,951–12,551,971	117.9 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	97.7 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	58.5 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	29.2 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	21.7 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	12.2 kb	Distal (>10kb) Multiome	254
chr19:12,664,457–12,664,721	4.7 kb	Proximal (<10kb)	64
chr19:12,666,317–12,667,225	2.6 kb	Proximal (<10kb) Multiome	495
chr19:12,669,351–12,669,939	140 bp	At TSS Multiome	777
chr19:12,672,121–12,672,300	2.7 kb	Proximal (<10kb)	206
chr19:12,676,416–12,676,669	7.0 kb	Proximal (<10kb)	276
chr19:12,681,003–12,682,117	12.0 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	27.2 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	33.8 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	53.0 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	54.7 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	65.3 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	67.7 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	88.4 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	96.9 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	106.0 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	108.5 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	113.3 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	120.6 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	122.1 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	124.3 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	132.5 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	137.1 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	156.4 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	163.2 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	164.5 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	169.0 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	171.4 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	178.3 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	198.2 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	203.9 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	212.1 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	216.0 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	221.6 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	243.9 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	250.0 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	264.4 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	269.0 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	276.5 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	287.8 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	296.0 kb	Distal (>10kb) Multiome	733

Genome Browser

Genomic view of the WDR83OS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.