Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nuclear exosome (RNase complex); nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WDR74. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR74 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR74, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:62,542,658–62,543,488 | 296.6 kb | Distal (>10kb) Multiome | 537 | |
| chr11:62,545,051–62,547,562 | 292.6 kb | Distal (>10kb) Multiome | 889 | |
| chr11:62,553,213–62,553,741 | 286.2 kb | Distal (>10kb) Multiome | 489 | |
| chr11:62,555,905–62,556,742 | 283.3 kb | Distal (>10kb) Multiome | 545 | |
| chr11:62,560,588–62,561,104 | 278.9 kb | Distal (>10kb) Multiome | 541 | |
| chr11:62,561,760–62,562,358 | 277.6 kb | Distal (>10kb) Multiome | 43 | |
| chr11:62,573,347–62,574,645 | 265.6 kb | Distal (>10kb) Multiome | 845 | |
| chr11:62,591,246–62,592,462 | 247.8 kb | Distal (>10kb) Multiome | 976 | |
| chr11:62,600,988–62,603,291 | 237.7 kb | Distal (>10kb) Multiome | 872 | |
| chr11:62,611,665–62,613,544 | 226.7 kb | Distal (>10kb) Multiome | 737 | |
| chr11:62,621,550–62,622,445 | 217.5 kb | Distal (>10kb) Multiome | 964 | |
| chr11:62,646,025–62,647,031 | 192.9 kb | Distal (>10kb) Multiome | 815 | |
| chr11:62,652,836–62,653,744 | 186.2 kb | Distal (>10kb) Multiome | 921 | |
| chr11:62,664,567–62,666,291 | 174.4 kb | Distal (>10kb) Multiome | 1020 | |
| chr11:62,671,328–62,672,522 | 167.8 kb | Distal (>10kb) Multiome | 882 | |
| chr11:62,705,543–62,707,930 | 133.3 kb | Distal (>10kb) Multiome | 760 | |
| chr11:62,708,691–62,710,293 | 130.0 kb | Distal (>10kb) Multiome | 531 | |
| chr11:62,726,557–62,728,947 | 112.0 kb | Distal (>10kb) Multiome | 1088 | |
| chr11:62,753,347–62,754,665 | 85.4 kb | Distal (>10kb) Multiome | 696 | |
| chr11:62,761,085–62,762,045 | 78.1 kb | Distal (>10kb) Multiome | 649 | |
| chr11:62,770,753–62,772,068 | 68.1 kb | Distal (>10kb) Multiome | 885 | |
| chr11:62,786,365–62,787,860 | 53.0 kb | Distal (>10kb) Multiome | 1073 | |
| chr11:62,791,569–62,792,385 | 47.6 kb | Distal (>10kb) Multiome | 805 | |
| chr11:62,804,451–62,807,080 | 34.1 kb | Distal (>10kb) Multiome | 994 | |
| chr11:62,831,037–62,832,904 | 7.6 kb | Proximal (<10kb) Multiome | 870 | |
| chr11:62,839,042–62,842,743 | 1.8 kb | Proximal (<10kb) Multiome | 1403 | |
| chr11:62,851,028–62,851,955 | 11.9 kb | Distal (>10kb) Multiome | 421 | |
| chr11:62,855,209–62,856,560 | 16.4 kb | Distal (>10kb) Multiome | 1071 | |
| chr11:62,862,252–62,862,948 | 23.1 kb | Distal (>10kb) Multiome | 360 | |
| chr11:62,880,343–62,881,977 | 41.3 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:62,909,033–62,909,985 | 69.8 kb | Distal (>10kb) Multiome | 366 |
Genomic view of the WDR74 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.