The protein encoded by this gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulates at the spindle poles and astral microtubules during mitosis. Reduced expression of this gene results in abnormalities in the size and morphology of the nucleus. Mutations in this gene have been associated with Galloway-Mowat syndrome PMID: 25466283), which is a rare autosomal recessive disorder that affects both the central nervous system and kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for WDR73. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR73 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR73, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:84,570,159–84,571,300 | 83.4 kb | Distal (>10kb) Multiome | 730 | |
| chr15:84,587,808–84,588,502 | 66.1 kb | Distal (>10kb) Multiome | 357 | |
| chr15:84,600,331–84,601,554 | 53.3 kb | Distal (>10kb) Multiome | 827 | |
| chr15:84,603,386–84,604,192 | 50.5 kb | Distal (>10kb) Multiome HiCAR | 119 | |
| chr15:84,630,983–84,631,898 | 22.9 kb | Distal (>10kb) Multiome | 649 | |
| chr15:84,633,275–84,634,337 | 20.5 kb | Distal (>10kb) Multiome | 621 | |
| chr15:84,653,715–84,654,595 | 94 bp | At TSS Multiome | 788 | |
| chr15:84,654,705–84,655,032 | 705 bp | At TSS | 393 | |
| chr15:84,657,788–84,658,916 | 4.1 kb | Proximal (<10kb) Multiome | 591 | |
| chr15:84,659,709–84,660,001 | 5.7 kb | Proximal (<10kb) | 26 | |
| chr15:84,715,472–84,717,226 | 62.0 kb | Distal (>10kb) Multiome | 972 | |
| chr15:84,734,887–84,735,749 | 80.9 kb | Distal (>10kb) Multiome | 614 | |
| chr15:84,747,459–84,749,457 | 94.2 kb | Distal (>10kb) Multiome | 852 | |
| chr15:84,816,861–84,818,557 | 163.5 kb | Distal (>10kb) Multiome HiCAR | 375 | |
| chr15:84,928,071–84,928,522 | 274.1 kb | Distal (>10kb) Multiome | 445 |
Genomic view of the WDR73 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.