This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for WDR44. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR44 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR44, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:118,116,068–118,117,653 | 229.3 kb | Distal (>10kb) Multiome | 357 | |
| chrX:118,345,383–118,346,825 | 86 bp | At TSS Multiome | 670 | |
| chrX:118,352,732–118,352,936 | 6.6 kb | Proximal (<10kb) | 12 | |
| chrX:118,353,064–118,353,531 | 7.0 kb | Proximal (<10kb) | 85 | |
| chrX:118,495,092–118,496,586 | 149.6 kb | Distal (>10kb) Multiome | 565 |
Genomic view of the WDR44 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.