This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WDR37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:930,617–932,295 | 117.7 kb | Distal (>10kb) Multiome | 658 | |
| chr10:973,560–974,740 | 75.5 kb | Distal (>10kb) Multiome | 415 | |
| chr10:987,707–988,902 | 61.2 kb | Distal (>10kb) Multiome | 842 | |
| chr10:1,048,018–1,050,104 | 357 bp | At TSS Multiome | 1021 | |
| chr10:1,050,268–1,050,408 | 731 bp | At TSS | 119 | |
| chr10:1,056,026–1,057,235 | 7.2 kb | Proximal (<10kb) Multiome | 863 | |
| chr10:1,310,139–1,310,799 | 260.9 kb | Distal (>10kb) Multiome | 73 |
Genomic view of the WDR37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.