Transcription factors with Perturb-seq knockdown data for WDR11-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR11-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR11-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:120,644,648–120,645,329 | 206.2 kb | Distal (>10kb) Multiome | 35 | |
| chr10:120,738,690–120,739,443 | 112.3 kb | Distal (>10kb) Multiome | 85 | |
| chr10:120,850,937–120,851,659 | 91 bp | At TSS Multiome | 1009 | |
| chr10:120,948,941–120,949,508 | 97.9 kb | Distal (>10kb) Multiome | 424 | |
| chr10:120,981,508–120,982,509 | 130.8 kb | Distal (>10kb) Multiome | 187 | |
| chr10:121,002,715–121,003,391 | 151.8 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the WDR11-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.