The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WDHD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDHD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDHD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:54,773,202–54,773,766 | 253.8 kb | Distal (>10kb) Multiome | 548 | |
| chr14:54,805,654–54,806,307 | 221.1 kb | Distal (>10kb) Multiome | 376 | |
| chr14:54,901,803–54,903,430 | 124.2 kb | Distal (>10kb) Multiome | 886 | |
| chr14:55,026,752–55,027,732 | 143 bp | At TSS Multiome | 918 | |
| chr14:55,051,004–55,052,455 | 24.6 kb | Distal (>10kb) Multiome | 1079 | |
| chr14:55,103,022–55,103,627 | 76.3 kb | Distal (>10kb) Multiome | 700 | |
| chr14:55,128,954–55,130,369 | 102.3 kb | Distal (>10kb) Multiome | 569 | |
| chr14:55,191,089–55,192,110 | 164.6 kb | Distal (>10kb) Multiome | 702 | |
| chr14:55,270,885–55,272,249 | 244.3 kb | Distal (>10kb) Multiome | 901 | |
| chr14:55,275,685–55,276,150 | 248.8 kb | Distal (>10kb) Multiome | 15 |
Genomic view of the WDHD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.