The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for WBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,587,697–75,590,735 | 265.9 kb | Distal (>10kb) Multiome | 744 | |
| chr17:75,633,694–75,634,328 | 221.3 kb | Distal (>10kb) Multiome | 559 | |
| chr17:75,666,763–75,667,767 | 188.1 kb | Distal (>10kb) Multiome | 783 | |
| chr17:75,720,933–75,721,693 | 134.0 kb | Distal (>10kb) Multiome | 509 | |
| chr17:75,753,534–75,754,285 | 101.5 kb | Distal (>10kb) Multiome | 699 | |
| chr17:75,764,621–75,765,674 | 90.2 kb | Distal (>10kb) Multiome | 769 | |
| chr17:75,778,786–75,780,191 | 75.4 kb | Distal (>10kb) Multiome | 1118 | |
| chr17:75,784,060–75,785,640 | 70.5 kb | Distal (>10kb) Multiome | 1176 | |
| chr17:75,827,420–75,828,293 | 27.5 kb | Distal (>10kb) Multiome | 404 | |
| chr17:75,830,158–75,830,695 | 24.9 kb | Distal (>10kb) Multiome | 190 | |
| chr17:75,832,912–75,833,396 | 22.2 kb | Distal (>10kb) Multiome | 104 | |
| chr17:75,845,103–75,845,662 | 9.9 kb | Proximal (<10kb) Multiome | 703 | |
| chr17:75,848,534–75,848,701 | 6.6 kb | Proximal (<10kb) | 280 | |
| chr17:75,854,955–75,856,363 | 204 bp | At TSS Multiome | 1038 | |
| chr17:75,877,486–75,878,900 | 22.7 kb | Distal (>10kb) Multiome | 884 | |
| chr17:75,896,392–75,897,754 | 41.6 kb | Distal (>10kb) Multiome | 831 | |
| chr17:75,904,371–75,905,532 | 49.7 kb | Distal (>10kb) Multiome | 1045 | |
| chr17:75,940,734–75,941,471 | 85.8 kb | Distal (>10kb) Multiome | 982 | |
| chr17:75,978,646–75,980,102 | 124.1 kb | Distal (>10kb) Multiome | 1090 | |
| chr17:75,983,292–75,984,226 | 128.5 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,014,120–76,014,727 | 159.1 kb | Distal (>10kb) Multiome | 489 | |
| chr17:76,029,331–76,030,158 | 174.3 kb | Distal (>10kb) Multiome | 722 | |
| chr17:76,072,173–76,072,853 | 217.3 kb | Distal (>10kb) Multiome | 893 | |
| chr17:76,074,414–76,075,796 | 219.3 kb | Distal (>10kb) Multiome | 280 | |
| chr17:76,103,272–76,104,343 | 248.5 kb | Distal (>10kb) Multiome | 798 | |
| chr17:76,121,142–76,122,265 | 266.3 kb | Distal (>10kb) Multiome | 689 | |
| chr17:76,132,004–76,133,216 | 277.4 kb | Distal (>10kb) Multiome | 536 | |
| chr17:76,135,151–76,135,652 | 279.9 kb | Distal (>10kb) Multiome | 104 | |
| chr17:76,141,012–76,141,958 | 286.1 kb | Distal (>10kb) Multiome | 616 |
Genomic view of the WBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.