This gene encodes a component of the WASH complex, which functions in the intracellular transport of endosomes. Mutations in this gene have been detected in individuals with autosomal recessive cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for WASHC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WASHC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WASHC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:103,956,327–103,957,900 | 1150.4 kb | Distal (>10kb) Multiome HiCAR | 1090 | |
| chr12:103,965,409–103,966,472 | 1141.8 kb | Distal (>10kb) Multiome HiCAR | 965 | |
| chr12:104,063,714–104,065,209 | 1043.2 kb | Distal (>10kb) Multiome HiCAR | 950 | |
| chr12:104,137,119–104,139,117 | 969.5 kb | Distal (>10kb) Multiome HiCAR | 796 | |
| chr12:104,215,473–104,216,381 | 891.9 kb | Distal (>10kb) Multiome HiCAR | 514 | |
| chr12:104,286,560–104,287,505 | 820.8 kb | Distal (>10kb) Multiome HiCAR | 878 | |
| chr12:104,288,643–104,289,175 | 818.9 kb | Distal (>10kb) Multiome HiCAR | 863 | |
| chr12:104,408,645–104,409,206 | 698.9 kb | Distal (>10kb) Multiome HiCAR | 348 | |
| chr12:104,414,328–104,416,462 | 692.9 kb | Distal (>10kb) Multiome HiCAR | 437 | |
| chr12:104,456,290–104,458,686 | 650.8 kb | Distal (>10kb) Multiome HiCAR | 684 | |
| chr12:104,957,697–104,958,992 | 149.4 kb | Distal (>10kb) Multiome | 811 | |
| chr12:104,986,118–104,986,938 | 121.4 kb | Distal (>10kb) Multiome | 665 | |
| chr12:105,083,642–105,085,161 | 23.1 kb | Distal (>10kb) Multiome | 490 | |
| chr12:105,107,164–105,108,312 | 12 bp | At TSS Multiome | 1033 | |
| chr12:105,235,605–105,236,419 | 128.3 kb | Distal (>10kb) Multiome | 802 | |
| chr12:105,330,237–105,331,332 | 222.9 kb | Distal (>10kb) Multiome | 497 |
Genomic view of the WASHC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.