Predicted to enable signaling receptor binding activity. Predicted to be active in cell surface and extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VWDE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VWDE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VWDE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:12,111,216–12,112,364 | 292.0 kb | Distal (>10kb) Multiome | 258 | |
| chr7:12,210,198–12,212,416 | 192.6 kb | Distal (>10kb) Multiome | 1158 | |
| chr7:12,329,006–12,329,738 | 74.5 kb | Distal (>10kb) Multiome | 220 | |
| chr7:12,403,223–12,404,775 | 50 bp | At TSS Multiome | 590 | |
| chr7:12,409,220–12,409,800 | 5.5 kb | Proximal (<10kb) | 17 | |
| chr7:12,423,909–12,424,530 | 20.4 kb | Distal (>10kb) Multiome | 203 | |
| chr7:12,570,159–12,571,611 | 167.1 kb | Distal (>10kb) Multiome | 430 | |
| chr7:12,686,188–12,688,064 | 283.7 kb | Distal (>10kb) Multiome | 1066 |
Genomic view of the VWDE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.