Predicted to enable ATP hydrolysis activity. Located in mitochondrion and peroxisome. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for VWA8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VWA8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VWA8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:41,959,613–41,959,784 | 1.3 kb | Proximal (<10kb) | 23 | |
| chr13:41,960,385–41,961,546 | 9 bp | At TSS Multiome | 878 | |
| chr13:41,973,102–41,973,730 | 12.4 kb | Distal (>10kb) Multiome | 122 | |
| chr13:42,039,804–42,041,490 | 79.3 kb | Distal (>10kb) Multiome | 682 | |
| chr13:42,047,409–42,049,725 | 88.0 kb | Distal (>10kb) Multiome | 677 |
Genomic view of the VWA8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.