Predicted to enable zinc ion binding activity. Involved in endosomal vesicle fusion. Located in early endosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VPS8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VPS8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VPS8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:184,513,458–184,514,228 | 298.3 kb | Distal (>10kb) Multiome | 391 | |
| chr3:184,525,317–184,526,423 | 286.1 kb | Distal (>10kb) Multiome | 281 | |
| chr3:184,558,752–184,559,234 | 253.3 kb | Distal (>10kb) Multiome | 58 | |
| chr3:184,561,059–184,562,613 | 250.6 kb | Distal (>10kb) Multiome HiCAR | 671 | |
| chr3:184,568,694–184,569,481 | 243.0 kb | Distal (>10kb) Multiome | 342 | |
| chr3:184,574,449–184,575,341 | 237.2 kb | Distal (>10kb) Multiome | 164 | |
| chr3:184,583,141–184,585,336 | 227.4 kb | Distal (>10kb) Multiome | 270 | |
| chr3:184,601,537–184,603,254 | 209.9 kb | Distal (>10kb) Multiome | 179 | |
| chr3:184,603,592–184,605,089 | 207.6 kb | Distal (>10kb) Multiome | 321 | |
| chr3:184,629,636–184,630,157 | 182.3 kb | Distal (>10kb) Multiome | 71 | |
| chr3:184,642,851–184,643,762 | 169.0 kb | Distal (>10kb) Multiome | 135 | |
| chr3:184,645,190–184,645,870 | 166.6 kb | Distal (>10kb) Multiome | 234 | |
| chr3:184,711,525–184,712,457 | 100.1 kb | Distal (>10kb) Multiome | 896 | |
| chr3:184,750,804–184,752,976 | 59.6 kb | Distal (>10kb) Multiome | 252 | |
| chr3:184,777,796–184,778,258 | 34.2 kb | Distal (>10kb) Multiome | 220 | |
| chr3:184,795,215–184,795,741 | 16.7 kb | Distal (>10kb) Multiome | 80 | |
| chr3:184,796,565–184,797,275 | 15.3 kb | Distal (>10kb) Multiome | 149 | |
| chr3:184,803,150–184,803,542 | 8.6 kb | Proximal (<10kb) | 237 | |
| chr3:184,811,949–184,812,608 | 24 bp | At TSS Multiome | 663 | |
| chr3:184,812,662–184,812,985 | 497 bp | At TSS | 246 | |
| chr3:184,906,987–184,907,510 | 95.0 kb | Distal (>10kb) Multiome | 18 |
Genomic view of the VPS8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.