This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for VPS26A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VPS26A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VPS26A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:68,826,917–68,827,679 | 296.9 kb | Distal (>10kb) Multiome | 577 | |
| chr10:68,900,541–68,901,785 | 223.1 kb | Distal (>10kb) Multiome | 1082 | |
| chr10:68,955,769–68,956,761 | 168.1 kb | Distal (>10kb) Multiome | 938 | |
| chr10:68,988,361–68,989,558 | 135.4 kb | Distal (>10kb) Multiome | 896 | |
| chr10:69,123,352–69,125,173 | 168 bp | At TSS Multiome | 918 | |
| chr10:69,179,817–69,180,725 | 55.9 kb | Distal (>10kb) Multiome | 900 | |
| chr10:69,317,873–69,319,610 | 194.4 kb | Distal (>10kb) Multiome | 675 | |
| chr10:69,329,639–69,330,213 | 205.7 kb | Distal (>10kb) Multiome | 155 | |
| chr10:69,375,626–69,376,241 | 251.7 kb | Distal (>10kb) Multiome | 178 | |
| chr10:69,392,338–69,392,832 | 268.4 kb | Distal (>10kb) Multiome | 454 | |
| chr10:69,408,469–69,409,338 | 284.6 kb | Distal (>10kb) Multiome | 705 |
Genomic view of the VPS26A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.