VIPR2

vasoactive intestinal peptide receptor 2 | VPAC2, VPAC2R

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]

Developmental clusters: GC6

Biological processes 23 terms

G protein-coupled peptide receptor activity (GO:0008528)G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor signaling pathway (GO:0007186)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)adenylate cyclase-modulating G protein-coupled receptor signaling pathway (GO:0007188)cell surface receptor signaling pathway (GO:0007166)cell-cell signaling (GO:0007267)membrane (GO:0016020)peptide hormone binding (GO:0017046)pituitary adenylate cyclase-activating polypeptide receptor activity (GO:0001634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)signal transduction (GO:0007165)transmembrane signaling receptor activity (GO:0004888)vasoactive intestinal polypeptide receptor activity (GO:0004999)vasoactive intestinal polypeptide receptor activity (GO:0004999)vasoactive intestinal polypeptide receptor activity (GO:0004999)

Expression (TPM)

TFs regulating VIPR2 0 TFs

Transcription factors with Perturb-seq knockdown data for VIPR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VIPR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to VIPR2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VIPR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:158,855,976–158,857,103	288.3 kb	Distal (>10kb) Multiome	944
chr7:158,863,230–158,864,395	280.9 kb	Distal (>10kb) Multiome	534
chr7:158,976,471–158,977,488	167.7 kb	Distal (>10kb) Multiome	458
chr7:159,030,257–159,031,567	114.1 kb	Distal (>10kb) Multiome	560
chr7:159,141,671–159,142,509	2.8 kb	Proximal (<10kb) Multiome	169
chr7:159,142,805–159,143,658	1.6 kb	Proximal (<10kb) Multiome	119
chr7:159,143,827–159,144,064	802 bp	At TSS	83
chr7:159,144,286–159,145,801	249 bp	At TSS Multiome	255

Genome Browser

Genomic view of the VIPR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.