This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for VDAC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VDAC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VDAC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:42,139,747–42,140,990 | 251.2 kb | Distal (>10kb) Multiome | 779 | |
| chr8:42,151,983–42,153,808 | 238.9 kb | Distal (>10kb) Multiome | 975 | |
| chr8:42,270,718–42,271,870 | 120.5 kb | Distal (>10kb) Multiome | 668 | |
| chr8:42,337,948–42,339,165 | 53.4 kb | Distal (>10kb) Multiome | 710 | |
| chr8:42,376,919–42,377,769 | 14.5 kb | Distal (>10kb) Multiome | 159 | |
| chr8:42,385,535–42,385,724 | 5.9 kb | Proximal (<10kb) | 305 | |
| chr8:42,391,151–42,392,597 | 78 bp | At TSS Multiome | 831 | |
| chr8:42,541,069–42,542,355 | 149.9 kb | Distal (>10kb) Multiome | 767 | |
| chr8:42,571,247–42,571,811 | 179.7 kb | Distal (>10kb) Multiome | 205 |
Genomic view of the VDAC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.