Predicted to enable oxidoreductase activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VAT1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VAT1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VAT1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:77,722,015–77,723,280 | 66.1 kb | Distal (>10kb) Multiome | 803 | |
| chr16:77,787,995–77,789,233 | 91 bp | At TSS Multiome | 389 | |
| chr16:77,789,340–77,790,175 | 777 bp | At TSS | 81 | |
| chr16:77,966,839–77,967,995 | 178.9 kb | Distal (>10kb) Multiome | 200 | |
| chr16:78,002,937–78,003,483 | 214.6 kb | Distal (>10kb) Multiome HiCAR | 327 | |
| chr16:78,045,597–78,046,283 | 257.5 kb | Distal (>10kb) Multiome | 839 | |
| chr16:78,071,935–78,072,676 | 283.8 kb | Distal (>10kb) Multiome | 218 |
Genomic view of the VAT1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.