Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for VAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,744,352–42,745,375 | 277.4 kb | Distal (>10kb) Multiome | 966 | |
| chr17:42,761,003–42,761,468 | 261.4 kb | Distal (>10kb) Multiome | 335 | |
| chr17:42,780,029–42,780,899 | 241.9 kb | Distal (>10kb) Multiome | 712 | |
| chr17:42,798,408–42,798,877 | 223.7 kb | Distal (>10kb) Multiome | 866 | |
| chr17:42,823,968–42,824,503 | 198.1 kb | Distal (>10kb) Multiome | 829 | |
| chr17:42,832,889–42,833,841 | 189.0 kb | Distal (>10kb) Multiome | 980 | |
| chr17:42,964,237–42,964,843 | 57.9 kb | Distal (>10kb) Multiome | 655 | |
| chr17:42,979,966–42,981,044 | 41.9 kb | Distal (>10kb) Multiome | 843 | |
| chr17:42,997,598–42,998,917 | 24.1 kb | Distal (>10kb) Multiome | 1112 | |
| chr17:43,021,026–43,022,568 | 11 bp | At TSS Multiome | 973 | |
| chr17:43,024,255–43,025,752 | 2.6 kb | Proximal (<10kb) Multiome | 811 | |
| chr17:43,124,981–43,125,702 | 103.1 kb | Distal (>10kb) Multiome | 837 | |
| chr17:43,169,744–43,171,576 | 148.8 kb | Distal (>10kb) Multiome | 1018 | |
| chr17:43,211,494–43,212,392 | 189.5 kb | Distal (>10kb) Multiome HiCAR | 586 |
Genomic view of the VAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.