VASP
vasodilator stimulated phosphoprotein

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

Member of: DE-4 DE-4.5 Developmental clusters: GC7
Biological processes 35 terms
SH3 domain binding (GO:0017124)actin binding (GO:0003779)actin cytoskeleton (GO:0015629)actin polymerization or depolymerization (GO:0008154)actin polymerization or depolymerization (GO:0008154)axon guidance (GO:0007411)bicellular tight junction (GO:0005923)cadherin binding (GO:0045296)cell junction (GO:0030054)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)extracellular exosome (GO:0070062)filopodium (GO:0030175)filopodium membrane (GO:0031527)focal adhesion (GO:0005925)focal adhesion (GO:0005925)focal adhesion (GO:0005925)focal adhesion (GO:0005925)glutamatergic synapse (GO:0098978)identical protein binding (GO:0042802)lamellipodium (GO:0030027)lamellipodium membrane (GO:0031258)neural tube closure (GO:0001843)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of actin filament polymerization (GO:0030838)positive regulation of actin filament polymerization (GO:0030838)postsynapse (GO:0098794)profilin binding (GO:0005522)profilin binding (GO:0005522)protein binding (GO:0005515)protein homotetramerization (GO:0051289)
Expression (TPM)
VASP — as a Regulated Gene

TFs regulating VASP 0 TFs

Transcription factors with Perturb-seq knockdown data for VASP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VASP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to VASP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VASP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:45,234,200–45,234,822 272.9 kb Distal (>10kb) Multiome 105
chr19:45,250,821–45,251,491 256.3 kb Distal (>10kb) Multiome 397
chr19:45,340,431–45,341,201 166.7 kb Distal (>10kb) Multiome 363
chr19:45,370,064–45,371,122 136.8 kb Distal (>10kb) Multiome 592
chr19:45,402,280–45,402,828 105.0 kb Distal (>10kb) Multiome 332
chr19:45,403,781–45,404,684 103.5 kb Distal (>10kb) Multiome 494
chr19:45,404,818–45,406,887 101.0 kb Distal (>10kb) Multiome 964
chr19:45,423,326–45,424,545 83.7 kb Distal (>10kb) Multiome 996
chr19:45,439,539–45,440,189 67.7 kb Distal (>10kb) Multiome 718
chr19:45,443,052–45,444,768 64.0 kb Distal (>10kb) Multiome 857
chr19:45,450,695–45,451,265 56.6 kb Distal (>10kb) Multiome 515
chr19:45,455,706–45,456,201 51.5 kb Distal (>10kb) Multiome 776
chr19:45,467,169–45,468,696 39.8 kb Distal (>10kb) Multiome 686
chr19:45,468,843–45,470,312 38.1 kb Distal (>10kb) Multiome 769
chr19:45,478,416–45,479,276 28.7 kb Distal (>10kb) Multiome 809
chr19:45,485,144–45,486,070 21.9 kb Distal (>10kb) Multiome 659
chr19:45,492,647–45,493,344 14.6 kb Distal (>10kb) Multiome 522
chr19:45,496,247–45,497,677 10.4 kb Distal (>10kb) Multiome 742
chr19:45,497,784–45,498,132 9.3 kb Proximal (<10kb) 18
chr19:45,498,270–45,499,916 7.9 kb Proximal (<10kb) Multiome 464
chr19:45,506,243–45,507,963 758 bp At TSS Multiome 969
chr19:45,508,291–45,509,751 1.2 kb Proximal (<10kb) Multiome 670
chr19:45,528,315–45,529,353 21.4 kb Distal (>10kb) Multiome 425
chr19:45,584,026–45,585,251 77.2 kb Distal (>10kb) Multiome 907
chr19:45,607,096–45,607,695 99.9 kb Distal (>10kb) Multiome 526
chr19:45,615,654–45,616,944 108.7 kb Distal (>10kb) Multiome 480
chr19:45,632,406–45,633,148 125.2 kb Distal (>10kb) Multiome 358
chr19:45,638,965–45,639,696 131.9 kb Distal (>10kb) Multiome 477
chr19:45,640,813–45,642,557 134.8 kb Distal (>10kb) Multiome 865
chr19:45,643,187–45,644,012 136.1 kb Distal (>10kb) Multiome 542
chr19:45,645,389–45,646,343 138.4 kb Distal (>10kb) Multiome 566
chr19:45,667,856–45,668,417 160.6 kb Distal (>10kb) Multiome 386
chr19:45,668,914–45,669,719 161.9 kb Distal (>10kb) Multiome 611
chr19:45,670,481–45,671,446 163.6 kb Distal (>10kb) Multiome 361
chr19:45,676,875–45,678,209 170.0 kb Distal (>10kb) Multiome 418
chr19:45,681,530–45,682,004 174.2 kb Distal (>10kb) Multiome 648
chr19:45,691,622–45,693,062 184.9 kb Distal (>10kb) Multiome 943
chr19:45,716,851–45,718,343 210.1 kb Distal (>10kb) Multiome 895
chr19:45,730,200–45,731,219 223.5 kb Distal (>10kb) Multiome 740
chr19:45,767,223–45,771,892 261.9 kb Distal (>10kb) Multiome 1161
chr19:45,779,258–45,780,150 272.1 kb Distal (>10kb) Multiome 445
chr19:45,792,338–45,793,273 285.4 kb Distal (>10kb) Multiome 609

Genome Browser

Genomic view of the VASP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:45,224,200 – 45,803,273
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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