Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell proliferation; negative regulation of lymphangiogenesis; and regulation of cellular senescence. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VASH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VASH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VASH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:76,563,507–76,564,002 | 197.7 kb | Distal (>10kb) Multiome | 13 | |
| chr14:76,695,366–76,696,205 | 65.7 kb | Distal (>10kb) Multiome | 33 | |
| chr14:76,761,176–76,762,367 | 214 bp | At TSS Multiome | 486 | |
| chr14:76,784,691–76,785,144 | 23.5 kb | Distal (>10kb) Multiome | 318 | |
| chr14:76,812,161–76,813,291 | 51.4 kb | Distal (>10kb) Multiome | 878 | |
| chr14:76,913,323–76,913,886 | 152.2 kb | Distal (>10kb) Multiome | 352 | |
| chr14:76,924,332–76,925,072 | 163.2 kb | Distal (>10kb) Multiome | 256 | |
| chr14:76,947,024–76,947,904 | 185.9 kb | Distal (>10kb) Multiome | 690 | |
| chr14:76,955,827–76,957,395 | 195.1 kb | Distal (>10kb) Multiome | 873 | |
| chr14:76,961,044–76,962,678 | 200.5 kb | Distal (>10kb) Multiome | 848 | |
| chr14:76,968,574–76,969,080 | 207.4 kb | Distal (>10kb) Multiome | 311 | |
| chr14:76,987,872–76,988,397 | 226.7 kb | Distal (>10kb) Multiome | 38 | |
| chr14:77,024,027–77,024,710 | 262.9 kb | Distal (>10kb) Multiome | 368 | |
| chr14:77,025,547–77,029,182 | 267.3 kb | Distal (>10kb) Multiome | 996 | |
| chr14:77,032,573–77,034,628 | 272.6 kb | Distal (>10kb) Multiome | 917 | |
| chr14:77,040,063–77,040,913 | 279.0 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the VASH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.