This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UVRAG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UVRAG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UVRAG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:75,524,766–75,526,517 | 289.2 kb | Distal (>10kb) Multiome | 663 | |
| chr11:75,547,627–75,548,081 | 267.4 kb | Distal (>10kb) Multiome | 241 | |
| chr11:75,554,271–75,554,862 | 260.6 kb | Distal (>10kb) Multiome | 441 | |
| chr11:75,559,107–75,559,968 | 255.7 kb | Distal (>10kb) Multiome | 262 | |
| chr11:75,561,674–75,564,448 | 253.0 kb | Distal (>10kb) Multiome | 813 | |
| chr11:75,582,925–75,584,268 | 231.3 kb | Distal (>10kb) Multiome | 489 | |
| chr11:75,667,242–75,669,059 | 147.6 kb | Distal (>10kb) Multiome | 328 | |
| chr11:75,768,053–75,769,178 | 46.6 kb | Distal (>10kb) Multiome | 885 | |
| chr11:75,780,954–75,781,467 | 34.0 kb | Distal (>10kb) Multiome | 37 | |
| chr11:75,811,570–75,811,924 | 3.3 kb | Proximal (<10kb) | 18 | |
| chr11:75,814,230–75,815,903 | 188 bp | At TSS Multiome | 814 | |
| chr11:75,979,208–75,979,827 | 164.3 kb | Distal (>10kb) Multiome | 62 | |
| chr11:76,152,038–76,152,868 | 337.2 kb | Distal (>10kb) Multiome HiCAR | 544 |
Genomic view of the UVRAG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.