This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for USP36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:78,723,107–78,723,697 | 117.3 kb | Distal (>10kb) Multiome | 236 | |
| chr17:78,781,367–78,783,044 | 58.4 kb | Distal (>10kb) Multiome | 847 | |
| chr17:78,839,825–78,841,566 | 130 bp | At TSS Multiome | 1124 | |
| chr17:78,924,768–78,925,859 | 84.6 kb | Distal (>10kb) Multiome | 498 | |
| chr17:78,971,335–78,971,892 | 130.7 kb | Distal (>10kb) Multiome HiCAR | 359 | |
| chr17:79,009,356–79,010,250 | 169.0 kb | Distal (>10kb) Multiome | 703 | |
| chr17:79,023,888–79,024,662 | 183.5 kb | Distal (>10kb) Multiome | 348 | |
| chr17:79,074,462–79,075,529 | 234.0 kb | Distal (>10kb) Multiome | 657 |
Genomic view of the USP36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.