This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UQCRQ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UQCRQ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UQCRQ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:132,655,819–132,656,736 | 210.4 kb | Distal (>10kb) Multiome | 235 | |
| chr5:132,736,904–132,738,172 | 129.1 kb | Distal (>10kb) Multiome | 706 | |
| chr5:132,746,941–132,748,230 | 118.9 kb | Distal (>10kb) Multiome | 369 | |
| chr5:132,776,389–132,777,915 | 89.3 kb | Distal (>10kb) Multiome | 587 | |
| chr5:132,813,194–132,815,033 | 52.1 kb | Distal (>10kb) Multiome | 418 | |
| chr5:132,822,729–132,823,756 | 43.4 kb | Distal (>10kb) Multiome | 258 | |
| chr5:132,825,176–132,826,484 | 40.9 kb | Distal (>10kb) Multiome | 208 | |
| chr5:132,829,647–132,831,156 | 36.3 kb | Distal (>10kb) Multiome | 877 | |
| chr5:132,866,046–132,867,186 | 118 bp | At TSS Multiome | 955 | |
| chr5:132,963,042–132,964,332 | 97.1 kb | Distal (>10kb) Multiome | 1068 | |
| chr5:133,026,009–133,027,021 | 159.9 kb | Distal (>10kb) Multiome | 754 | |
| chr5:133,051,201–133,052,938 | 185.3 kb | Distal (>10kb) Multiome | 1018 |
Genomic view of the UQCRQ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.