This gene encodes a transmembrane protein that is structurally similar to the mouse basic fibroblast growth factor repressed ZIC-binding protein. In mouse this protein may be involved in fibroblast growth factor regulated growth control. In humans, polymorphisms in this gene are associated with variation in human height and osteoarthritis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for UQCC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UQCC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UQCC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:35,146,563–35,147,734 | 264.7 kb | Distal (>10kb) Multiome | 992 | |
| chr20:35,171,731–35,172,358 | 240.0 kb | Distal (>10kb) Multiome | 383 | |
| chr20:35,174,680–35,175,277 | 237.0 kb | Distal (>10kb) Multiome | 635 | |
| chr20:35,262,839–35,263,582 | 148.6 kb | Distal (>10kb) Multiome | 336 | |
| chr20:35,269,197–35,269,766 | 142.5 kb | Distal (>10kb) Multiome | 447 | |
| chr20:35,277,415–35,278,519 | 133.9 kb | Distal (>10kb) Multiome | 575 | |
| chr20:35,284,235–35,285,360 | 127.2 kb | Distal (>10kb) Multiome | 950 | |
| chr20:35,303,859–35,304,479 | 107.9 kb | Distal (>10kb) Multiome | 484 | |
| chr20:35,411,901–35,412,241 | at TSS | At TSS | 970 | |
| chr20:35,454,521–35,455,845 | 43.2 kb | Distal (>10kb) Multiome | 1059 | |
| chr20:35,539,672–35,540,321 | 128.0 kb | Distal (>10kb) Multiome | 311 | |
| chr20:35,541,280–35,542,685 | 130.1 kb | Distal (>10kb) Multiome | 849 | |
| chr20:35,600,739–35,601,999 | 189.6 kb | Distal (>10kb) Multiome | 575 | |
| chr20:35,604,921–35,605,589 | 193.4 kb | Distal (>10kb) Multiome | 27 | |
| chr20:35,615,559–35,617,919 | 205.9 kb | Distal (>10kb) Multiome | 1169 | |
| chr20:35,618,589–35,619,849 | 207.5 kb | Distal (>10kb) Multiome | 865 | |
| chr20:35,664,428–35,665,171 | 253.0 kb | Distal (>10kb) Multiome | 1018 | |
| chr20:35,698,724–35,699,893 | 287.4 kb | Distal (>10kb) Multiome | 1035 |
Genomic view of the UQCC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.