This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for UPP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UPP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UPP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:47,896,547–47,897,454 | 192.3 kb | Distal (>10kb) Multiome | 134 | |
| chr7:47,978,959–47,980,059 | 109.6 kb | Distal (>10kb) Multiome HiCAR | 1028 | |
| chr7:47,989,729–47,990,281 | 99.2 kb | Distal (>10kb) Multiome | 165 | |
| chr7:47,991,664–47,992,347 | 97.2 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr7:48,035,130–48,036,475 | 53.7 kb | Distal (>10kb) Multiome HiCAR | 452 | |
| chr7:48,038,675–48,039,550 | 50.2 kb | Distal (>10kb) Multiome HiCAR | 70 | |
| chr7:48,088,257–48,090,514 | 47 bp | At TSS Multiome | 970 |
Genomic view of the UPP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.