The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for UPK1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UPK1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UPK1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,471,034–35,471,539 | 195.2 kb | Distal (>10kb) Multiome | 15 | |
| chr19:35,509,786–35,510,900 | 156.0 kb | Distal (>10kb) Multiome | 650 | |
| chr19:35,545,067–35,546,126 | 120.9 kb | Distal (>10kb) Multiome | 879 | |
| chr19:35,557,343–35,558,684 | 108.4 kb | Distal (>10kb) Multiome | 452 | |
| chr19:35,612,546–35,613,176 | 53.8 kb | Distal (>10kb) Multiome | 778 | |
| chr19:35,628,465–35,629,474 | 37.6 kb | Distal (>10kb) Multiome | 889 | |
| chr19:35,641,602–35,642,192 | 24.8 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,643,064–35,645,730 | 23.0 kb | Distal (>10kb) Multiome | 1010 | |
| chr19:35,648,040–35,648,575 | 18.3 kb | Distal (>10kb) Multiome | 599 | |
| chr19:35,673,179–35,673,643 | 6.9 kb | Proximal (<10kb) Multiome | 311 | |
| chr19:35,702,152–35,702,985 | 36.0 kb | Distal (>10kb) Multiome | 662 | |
| chr19:35,716,025–35,718,811 | 51.2 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:35,740,083–35,741,430 | 74.3 kb | Distal (>10kb) Multiome | 829 | |
| chr19:35,744,481–35,746,086 | 78.8 kb | Distal (>10kb) Multiome | 679 | |
| chr19:35,748,170–35,749,017 | 81.9 kb | Distal (>10kb) Multiome | 749 | |
| chr19:35,757,432–35,758,657 | 91.6 kb | Distal (>10kb) Multiome | 851 | |
| chr19:35,767,601–35,768,256 | 101.4 kb | Distal (>10kb) Multiome | 276 | |
| chr19:35,775,066–35,776,063 | 108.9 kb | Distal (>10kb) Multiome | 474 | |
| chr19:35,784,357–35,785,306 | 118.2 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,860,621–35,861,651 | 194.8 kb | Distal (>10kb) Multiome | 299 | |
| chr19:35,868,369–35,868,860 | 202.0 kb | Distal (>10kb) Multiome | 320 | |
| chr19:35,869,343–35,870,482 | 203.4 kb | Distal (>10kb) Multiome | 492 | |
| chr19:35,899,240–35,900,760 | 233.2 kb | Distal (>10kb) Multiome | 751 | |
| chr19:35,931,342–35,932,167 | 265.2 kb | Distal (>10kb) Multiome | 835 | |
| chr19:35,936,083–35,936,704 | 269.9 kb | Distal (>10kb) Multiome | 417 |
Genomic view of the UPK1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.