The NALCN channel is responsible for Na(+) leak currents. The protein encoded by this gene, along with UNC80, is an accessory subunit of the NALCN channel that contributes to the Ca(2+) sensitivity of the channel. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for UNC79. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNC79 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNC79, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:93,184,056–93,185,524 | 245.4 kb | Distal (>10kb) Multiome | 831 | |
| chr14:93,206,605–93,207,773 | 223.1 kb | Distal (>10kb) Multiome | 809 | |
| chr14:93,332,195–93,333,678 | 97.3 kb | Distal (>10kb) Multiome | 770 | |
| chr14:93,422,034–93,422,544 | 8.0 kb | Proximal (<10kb) Multiome | 15 | |
| chr14:93,430,263–93,431,562 | 369 bp | At TSS Multiome | 232 | |
| chr14:93,669,677–93,670,358 | 239.6 kb | Distal (>10kb) Multiome | 147 | |
| chr14:93,687,932–93,689,042 | 258.2 kb | Distal (>10kb) Multiome | 186 |
Genomic view of the UNC79 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.