This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for UMPS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UMPS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UMPS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:124,545,526–124,546,488 | 184.4 kb | Distal (>10kb) Multiome | 30 | |
| chr3:124,584,341–124,585,325 | 145.7 kb | Distal (>10kb) Multiome | 571 | |
| chr3:124,730,263–124,730,718 | 14 bp | At TSS Multiome | 844 | |
| chr3:124,757,599–124,758,508 | 27.5 kb | Distal (>10kb) Multiome | 59 | |
| chr3:124,827,544–124,828,219 | 97.3 kb | Distal (>10kb) Multiome | 128 | |
| chr3:124,886,097–124,888,040 | 157.1 kb | Distal (>10kb) Multiome | 804 | |
| chr3:124,888,393–124,889,745 | 158.8 kb | Distal (>10kb) Multiome | 135 | |
| chr3:124,910,445–124,911,085 | 180.3 kb | Distal (>10kb) Multiome | 133 |
Genomic view of the UMPS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.