UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Transcription factors with Perturb-seq knockdown data for UGGT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UGGT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UGGT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:96,052,713–96,054,225 | 95 bp | At TSS Multiome | 890 | |
| chr13:96,054,367–96,054,811 | 966 bp | At TSS | 54 | |
| chr13:96,080,723–96,081,286 | 27.6 kb | Distal (>10kb) Multiome | 30 | |
| chr13:96,089,540–96,092,351 | 36.8 kb | Distal (>10kb) Multiome | 487 | |
| chr13:96,179,087–96,180,020 | 126.1 kb | Distal (>10kb) Multiome | 69 | |
| chr13:96,248,904–96,249,645 | 195.9 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the UGGT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.