This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for UGCG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UGCG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UGCG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:111,597,856–111,598,818 | 298.8 kb | Distal (>10kb) Multiome | 424 | |
| chr9:111,599,075–111,600,234 | 297.1 kb | Distal (>10kb) Multiome | 464 | |
| chr9:111,603,576–111,604,637 | 292.7 kb | Distal (>10kb) Multiome | 88 | |
| chr9:111,630,618–111,631,920 | 265.5 kb | Distal (>10kb) Multiome | 1034 | |
| chr9:111,660,898–111,662,420 | 235.3 kb | Distal (>10kb) Multiome | 606 | |
| chr9:111,662,977–111,663,798 | 233.4 kb | Distal (>10kb) Multiome | 132 | |
| chr9:111,896,061–111,897,616 | 22 bp | At TSS Multiome | 886 | |
| chr9:112,065,640–112,066,613 | 169.2 kb | Distal (>10kb) Multiome HiCAR | 338 | |
| chr9:112,097,640–112,098,616 | 201.2 kb | Distal (>10kb) Multiome | 337 | |
| chr9:112,174,728–112,175,784 | 278.3 kb | Distal (>10kb) Multiome | 620 |
Genomic view of the UGCG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.