Predicted to enable ubiquitin binding activity. Predicted to be involved in endosome to lysosome transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UEVLD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UEVLD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UEVLD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:18,318,016–18,318,522 | 270.5 kb | Distal (>10kb) Multiome | 49 | |
| chr11:18,321,766–18,322,926 | 266.4 kb | Distal (>10kb) Multiome | 1044 | |
| chr11:18,393,759–18,396,665 | 192.5 kb | Distal (>10kb) Multiome | 1203 | |
| chr11:18,526,292–18,527,325 | 61.9 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:18,579,112–18,579,564 | 9.2 kb | Proximal (<10kb) | 288 | |
| chr11:18,588,293–18,589,047 | 9 bp | At TSS Multiome | 837 | |
| chr11:18,589,149–18,589,251 | 432 bp | At TSS | 175 | |
| chr11:18,633,863–18,635,078 | 45.8 kb | Distal (>10kb) Multiome | 834 | |
| chr11:18,698,354–18,699,356 | 110.0 kb | Distal (>10kb) Multiome | 586 | |
| chr11:18,720,706–18,722,495 | 132.6 kb | Distal (>10kb) Multiome HiCAR | 447 | |
| chr11:18,790,876–18,792,822 | 203.1 kb | Distal (>10kb) Multiome | 294 |
Genomic view of the UEVLD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.