The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for UCHL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UCHL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UCHL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:75,326,127–75,326,956 | 222.9 kb | Distal (>10kb) Multiome | 339 | |
| chr13:75,480,662–75,482,799 | 67.0 kb | Distal (>10kb) Multiome | 921 | |
| chr13:75,537,361–75,538,569 | 11.5 kb | Distal (>10kb) Multiome | 904 | |
| chr13:75,548,880–75,550,494 | 91 bp | At TSS Multiome | 850 | |
| chr13:75,635,128–75,637,654 | 86.5 kb | Distal (>10kb) Multiome | 863 | |
| chr13:75,802,491–75,803,843 | 253.9 kb | Distal (>10kb) Multiome | 268 | |
| chr13:76,991,141–76,993,015 | 1442.6 kb | Distal (>10kb) Multiome HiCAR | 951 |
Genomic view of the UCHL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.