p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for UBXN8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBXN8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBXN8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:30,541,211–30,542,932 | 202.5 kb | Distal (>10kb) Multiome | 253 | |
| chr8:30,555,639–30,556,644 | 188.2 kb | Distal (>10kb) Multiome | 396 | |
| chr8:30,657,598–30,658,716 | 85.9 kb | Distal (>10kb) Multiome | 834 | |
| chr8:30,727,108–30,728,427 | 16.3 kb | Distal (>10kb) Multiome | 986 | |
| chr8:30,743,665–30,744,537 | 60 bp | At TSS Multiome | 789 | |
| chr8:30,811,955–30,813,256 | 68.6 kb | Distal (>10kb) Multiome | 824 | |
| chr8:30,817,124–30,817,779 | 73.3 kb | Distal (>10kb) Multiome | 166 | |
| chr8:30,911,618–30,912,683 | 168.0 kb | Distal (>10kb) Multiome | 460 | |
| chr8:31,032,234–31,034,302 | 289.5 kb | Distal (>10kb) Multiome | 723 |
Genomic view of the UBXN8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.