This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UBR5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBR5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBR5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:102,123,582–102,124,596 | 288.7 kb | Distal (>10kb) Multiome | 301 | |
| chr8:102,202,111–102,202,781 | 210.3 kb | Distal (>10kb) Multiome | 79 | |
| chr8:102,238,283–102,240,136 | 173.5 kb | Distal (>10kb) Multiome | 1019 | |
| chr8:102,352,485–102,353,157 | 59.8 kb | Distal (>10kb) Multiome | 159 | |
| chr8:102,411,265–102,413,321 | 145 bp | At TSS Multiome | 983 | |
| chr8:102,416,495–102,416,816 | 3.8 kb | Proximal (<10kb) | 269 | |
| chr8:102,417,000–102,417,212 | 4.3 kb | Proximal (<10kb) | 65 | |
| chr8:102,528,491–102,529,202 | 116.2 kb | Distal (>10kb) Multiome | 532 | |
| chr8:102,535,757–102,536,632 | 123.4 kb | Distal (>10kb) Multiome HiCAR | 367 | |
| chr8:102,600,735–102,601,194 | 188.4 kb | Distal (>10kb) Multiome | 514 | |
| chr8:102,653,614–102,656,985 | 241.4 kb | Distal (>10kb) Multiome | 1123 |
Genomic view of the UBR5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.