Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:29,594,380–29,596,128 | 254.8 kb | Distal (>10kb) Multiome | 706 | |
| chr13:29,841,560–29,842,260 | 8.4 kb | Proximal (<10kb) | 121 | |
| chr13:29,849,790–29,850,932 | 9 bp | At TSS Multiome | 723 | |
| chr13:29,923,822–29,924,462 | 73.7 kb | Distal (>10kb) Multiome HiCAR | 738 | |
| chr13:29,942,955–29,944,030 | 92.8 kb | Distal (>10kb) Multiome | 131 | |
| chr13:30,031,400–30,031,991 | 181.0 kb | Distal (>10kb) Multiome | 77 | |
| chr13:30,042,195–30,043,012 | 191.8 kb | Distal (>10kb) Multiome | 60 | |
| chr13:30,051,597–30,052,771 | 201.7 kb | Distal (>10kb) Multiome | 229 | |
| chr13:30,076,912–30,078,136 | 226.9 kb | Distal (>10kb) Multiome | 193 | |
| chr13:30,112,660–30,113,240 | 262.3 kb | Distal (>10kb) Multiome HiCAR | 269 | |
| chr13:30,114,642–30,115,460 | 264.5 kb | Distal (>10kb) Multiome HiCAR | 617 | |
| chr13:30,132,589–30,133,092 | 282.2 kb | Distal (>10kb) Multiome | 342 |
Genomic view of the UBL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.