This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for UBE2W. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2W upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2W, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:73,745,665–73,747,641 | 131.8 kb | Distal (>10kb) Multiome | 863 | |
| chr8:73,877,680–73,879,555 | 77 bp | At TSS Multiome | 897 | |
| chr8:73,880,230–73,880,553 | 1.4 kb | Proximal (<10kb) | 163 | |
| chr8:73,971,155–73,973,036 | 93.5 kb | Distal (>10kb) Multiome | 889 | |
| chr8:73,975,889–73,976,754 | 97.4 kb | Distal (>10kb) Multiome | 855 | |
| chr8:74,108,336–74,109,315 | 229.9 kb | Distal (>10kb) Multiome | 221 | |
| chr8:74,115,763–74,116,601 | 237.3 kb | Distal (>10kb) Multiome | 93 | |
| chr8:74,163,711–74,164,253 | 285.2 kb | Distal (>10kb) Multiome | 63 |
Genomic view of the UBE2W locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.