Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBE2Q2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2Q2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2Q2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:75,579,138–75,580,015 | 263.8 kb | Distal (>10kb) Multiome | 683 | |
| chr15:75,624,816–75,626,356 | 217.6 kb | Distal (>10kb) Multiome | 987 | |
| chr15:75,639,562–75,640,798 | 203.0 kb | Distal (>10kb) Multiome | 999 | |
| chr15:75,647,017–75,648,674 | 195.5 kb | Distal (>10kb) Multiome | 795 | |
| chr15:75,672,794–75,673,400 | 170.3 kb | Distal (>10kb) Multiome | 226 | |
| chr15:75,712,716–75,713,248 | 130.4 kb | Distal (>10kb) Multiome | 318 | |
| chr15:75,738,177–75,739,332 | 104.6 kb | Distal (>10kb) Multiome | 611 | |
| chr15:75,758,383–75,758,865 | 84.7 kb | Distal (>10kb) Multiome | 550 | |
| chr15:75,823,901–75,824,543 | 19.2 kb | Distal (>10kb) Multiome | 98 | |
| chr15:75,842,738–75,844,503 | 64 bp | At TSS Multiome | 842 | |
| chr15:75,903,363–75,904,635 | 60.6 kb | Distal (>10kb) Multiome | 958 | |
| chr15:76,033,743–76,034,907 | 191.0 kb | Distal (>10kb) Multiome | 131 | |
| chr15:76,058,953–76,060,346 | 216.5 kb | Distal (>10kb) Multiome | 463 | |
| chr15:76,139,361–76,140,331 | 296.4 kb | Distal (>10kb) Multiome | 257 |
Genomic view of the UBE2Q2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.