This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UBASH3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBASH3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBASH3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:122,439,845–122,441,657 | 215.0 kb | Distal (>10kb) Multiome | 365 | |
| chr11:122,556,541–122,557,119 | 98.9 kb | Distal (>10kb) Multiome | 192 | |
| chr11:122,559,577–122,560,226 | 95.8 kb | Distal (>10kb) Multiome | 136 | |
| chr11:122,655,417–122,657,184 | 74 bp | At TSS Multiome | 620 | |
| chr11:122,882,666–122,883,545 | 227.3 kb | Distal (>10kb) Multiome | 409 |
Genomic view of the UBASH3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.