Transcription factors with Perturb-seq knockdown data for UBALD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBALD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBALD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,978,646–75,980,102 | 286.0 kb | Distal (>10kb) Multiome | 1090 | |
| chr17:75,983,292–75,984,226 | 281.5 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,014,120–76,014,727 | 250.9 kb | Distal (>10kb) Multiome | 489 | |
| chr17:76,029,331–76,030,158 | 235.7 kb | Distal (>10kb) Multiome | 722 | |
| chr17:76,072,173–76,072,853 | 192.8 kb | Distal (>10kb) Multiome | 893 | |
| chr17:76,074,414–76,075,796 | 190.7 kb | Distal (>10kb) Multiome | 280 | |
| chr17:76,103,272–76,104,343 | 161.6 kb | Distal (>10kb) Multiome HiCAR | 798 | |
| chr17:76,121,142–76,122,265 | 143.8 kb | Distal (>10kb) Multiome | 689 | |
| chr17:76,132,004–76,133,216 | 132.6 kb | Distal (>10kb) Multiome | 536 | |
| chr17:76,135,151–76,135,652 | 130.1 kb | Distal (>10kb) Multiome | 104 | |
| chr17:76,141,012–76,141,958 | 124.0 kb | Distal (>10kb) Multiome | 616 | |
| chr17:76,240,278–76,241,169 | 24.7 kb | Distal (>10kb) Multiome | 560 | |
| chr17:76,259,315–76,259,732 | 5.6 kb | Proximal (<10kb) | 195 | |
| chr17:76,264,834–76,266,286 | 202 bp | At TSS Multiome | 868 | |
| chr17:76,353,245–76,354,535 | 88.7 kb | Distal (>10kb) Multiome | 1071 | |
| chr17:76,383,686–76,385,081 | 119.2 kb | Distal (>10kb) Multiome | 823 | |
| chr17:76,385,493–76,386,382 | 120.7 kb | Distal (>10kb) Multiome | 935 | |
| chr17:76,452,469–76,453,735 | 187.9 kb | Distal (>10kb) Multiome | 726 | |
| chr17:76,500,907–76,502,333 | 236.1 kb | Distal (>10kb) Multiome | 728 | |
| chr17:76,506,248–76,506,840 | 241.2 kb | Distal (>10kb) Multiome | 550 | |
| chr17:76,537,326–76,538,627 | 272.4 kb | Distal (>10kb) Multiome | 192 | |
| chr17:76,540,451–76,541,323 | 275.6 kb | Distal (>10kb) Multiome | 478 | |
| chr17:76,557,376–76,557,942 | 292.3 kb | Distal (>10kb) Multiome | 906 |
Genomic view of the UBALD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.