Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UBA52. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBA52 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBA52, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:18,278,462–18,282,788 | 290.1 kb | Distal (>10kb) Multiome | 1184 | |
| chr19:18,287,827–18,288,359 | 283.9 kb | Distal (>10kb) Multiome | 221 | |
| chr19:18,291,350–18,293,764 | 279.9 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:18,322,635–18,323,493 | 248.6 kb | Distal (>10kb) Multiome | 814 | |
| chr19:18,328,417–18,328,936 | 243.2 kb | Distal (>10kb) Multiome | 488 | |
| chr19:18,339,807–18,340,160 | 231.9 kb | Distal (>10kb) Multiome | 249 | |
| chr19:18,340,428–18,341,393 | 231.3 kb | Distal (>10kb) Multiome | 747 | |
| chr19:18,373,917–18,374,961 | 197.3 kb | Distal (>10kb) Multiome | 971 | |
| chr19:18,388,239–18,388,884 | 183.3 kb | Distal (>10kb) Multiome | 910 | |
| chr19:18,416,224–18,418,189 | 155.2 kb | Distal (>10kb) Multiome | 893 | |
| chr19:18,418,296–18,420,432 | 152.4 kb | Distal (>10kb) Multiome | 773 | |
| chr19:18,428,554–18,429,777 | 142.7 kb | Distal (>10kb) Multiome | 489 | |
| chr19:18,433,114–18,434,328 | 137.7 kb | Distal (>10kb) Multiome | 446 | |
| chr19:18,436,634–18,439,166 | 134.6 kb | Distal (>10kb) Multiome HiCAR | 799 | |
| chr19:18,521,058–18,522,859 | 49.5 kb | Distal (>10kb) Multiome | 849 | |
| chr19:18,543,118–18,544,249 | 28.2 kb | Distal (>10kb) Multiome | 574 | |
| chr19:18,557,570–18,558,196 | 14.1 kb | Distal (>10kb) Multiome | 738 | |
| chr19:18,571,234–18,572,258 | 135 bp | At TSS Multiome | 972 | |
| chr19:18,588,272–18,591,023 | 18.8 kb | Distal (>10kb) Multiome | 1174 | |
| chr19:18,593,729–18,595,402 | 22.6 kb | Distal (>10kb) Multiome | 464 | |
| chr19:18,611,391–18,612,134 | 39.9 kb | Distal (>10kb) Multiome | 340 | |
| chr19:18,635,894–18,637,555 | 64.8 kb | Distal (>10kb) Multiome | 617 | |
| chr19:18,682,925–18,684,360 | 111.8 kb | Distal (>10kb) Multiome | 701 | |
| chr19:18,785,146–18,785,600 | 213.5 kb | Distal (>10kb) Multiome | 247 | |
| chr19:18,831,386–18,833,070 | 260.0 kb | Distal (>10kb) Multiome | 833 | |
| chr19:18,870,063–18,870,526 | 298.6 kb | Distal (>10kb) Multiome | 148 | |
| chr19:18,895,036–18,896,591 | 324.3 kb | Distal (>10kb) Multiome HiCAR | 554 |
Genomic view of the UBA52 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.