Enables RNA binding activity. Predicted to be involved in RNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for U2SURP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = U2SURP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of U2SURP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:142,595,928–142,596,960 | 405.2 kb | Distal (>10kb) Multiome HiCAR | 962 | |
| chr3:142,723,641–142,725,348 | 277.3 kb | Distal (>10kb) Multiome | 876 | |
| chr3:142,863,026–142,863,734 | 138.3 kb | Distal (>10kb) Multiome | 186 | |
| chr3:142,866,818–142,867,310 | 134.5 kb | Distal (>10kb) Multiome | 187 | |
| chr3:142,888,221–142,889,512 | 112.7 kb | Distal (>10kb) Multiome | 691 | |
| chr3:142,962,519–142,964,437 | 37.9 kb | Distal (>10kb) Multiome | 781 | |
| chr3:143,000,964–143,002,299 | 68 bp | At TSS Multiome | 1014 | |
| chr3:143,118,976–143,122,095 | 119.8 kb | Distal (>10kb) Multiome | 740 |
Genomic view of the U2SURP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.