This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for TXNDC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TXNDC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TXNDC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:7,615,396–7,616,491 | 294.8 kb | Distal (>10kb) Multiome | 297 | |
| chr6:7,672,770–7,673,478 | 237.5 kb | Distal (>10kb) Multiome | 337 | |
| chr6:7,725,533–7,728,906 | 184.7 kb | Distal (>10kb) Multiome | 639 | |
| chr6:7,899,453–7,900,085 | 11.1 kb | Distal (>10kb) Multiome | 251 | |
| chr6:7,909,415–7,911,636 | 732 bp | At TSS Multiome | 964 | |
| chr6:8,063,680–8,065,380 | 153.6 kb | Distal (>10kb) Multiome | 998 | |
| chr6:8,101,740–8,103,121 | 191.8 kb | Distal (>10kb) Multiome | 850 |
Genomic view of the TXNDC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.