Predicted to be involved in protein secretion and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TVP23B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TVP23B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TVP23B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:18,773,597–18,773,831 | 7.5 kb | Proximal (<10kb) | 28 | |
| chr17:18,781,005–18,781,365 | at TSS | At TSS | 382 | |
| chr17:18,785,755–18,786,420 | 4.9 kb | Proximal (<10kb) Multiome | 91 | |
| chr17:18,855,845–18,856,439 | 75.0 kb | Distal (>10kb) Multiome | 582 | |
| chr17:18,857,671–18,858,643 | 76.8 kb | Distal (>10kb) Multiome | 600 | |
| chr17:19,003,639–19,005,123 | 223.1 kb | Distal (>10kb) Multiome | 733 |
Genomic view of the TVP23B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.